The liberals at whom I used to laugh were the ones who were right—for they were living in the present while I had been living in the past. They had been using science while I had been using romantic antiquarianism.
— H.P. Lovecraft, letter to Jennie K. Plaiser (8 July 1936)
In any field, find the strangest thing and then explore it.
— John Archibald Wheeler, theoretical physicist
Science is a systematic enterprise that builds and organizes knowledge in the form of testable explanations and predictions about the universe. In a universe where Lovecraft's stories are true, science would stumble upon the differences sooner or later, and adapt to them. For instance, Johansen's tale in The Call of Cthulhu has been suggested to constitute ”nontechnical observations of an intelligent man who did not understand how to describe what he was seeing”, namely spacetime curvatures local to R'lyeh.1
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Some concepts in science that can be useful in explaining Mythos phenomena and why they are not understood by humans.
- Quantum fluctuation. The amount of energy in a point in space varies even in a perfect vacuum and without radiation. This can be described as “virtual” particles and antiparticles forming and annihilating from apparently nothing.
- Quantum foam. According to Einstein's theory of general relativity, energy curves space time, and therefore, at small scales, the energy of quantum fluctuation should give space-time a “foamy” character. This has been called the foundation of the fabric of the universe.